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Therapeutic Drug Levels

Valproic Acid Level

Normal range 50-100 µg/mL (347-693 µmol/L SI). Specimen: Serum (trough).

Also known as: Depakote level, valproate.

50-100 µg/mLToxicity threshold: read below

Reference range

Conventionalµg/mL
50100
SIµmol/L
347693

Combined adult band. LabVals does not publish separate men's, women's, or pediatric ranges for Valproic Acid Level; those can be narrower than the band shown.

Valproic Acid Level reference range, specimen, and conversion details
SpecimenSerum (trough)
Conventional range50-100 µg/mL
SI range347-693 µmol/L
Conversion factor×6.93 (conventional → SI)
Toxicity threshold> 100-150 µg/mL (sedation, tremor)
PanelTherapeutic Drug Levels

Convert any Valproic Acid Level result between units on the unit converter.

What is the normal range for Valproic Acid Level?

The standard teaching reference range for Valproic Acid Level is 50-100 µg/mL in conventional units, or 347-693 µmol/L in SI units. This value is measured in serum (trough).

What toxicity threshold is taught for Valproic Acid Level?

For Valproic Acid Level, the commonly taught toxicity threshold is: > 100-150 µg/mL (sedation, tremor).

Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population - always use the range printed on the actual result.

At the bedside

Nursing considerations

  • Monitor liver function, ammonia, and platelets; valproate can cause hepatotoxicity and thrombocytopenia.
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