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Therapeutic Drug Levels

Phenytoin Level

Normal range 10-20 µg/mL (40-79 µmol/L SI). Specimen: Serum (trough).

Also known as: Dilantin level.

10-20 µg/mLToxicity threshold: read below

Reference range

Conventionalµg/mL
1020
SIµmol/L
4079

Combined adult band. LabVals does not publish separate men's, women's, or pediatric ranges for Phenytoin Level; those can be narrower than the band shown.

Phenytoin Level reference range, specimen, and conversion details
SpecimenSerum (trough)
Conventional range10-20 µg/mL
SI range40-79 µmol/L
Conversion factor×3.96 (conventional → SI)
Toxicity threshold> 20 µg/mL (nystagmus, ataxia); > 30 confusion
PanelTherapeutic Drug Levels

Convert any Phenytoin Level result between units on the unit converter.

What is the normal range for Phenytoin Level?

The standard teaching reference range for Phenytoin Level is 10-20 µg/mL in conventional units, or 40-79 µmol/L in SI units. This value is measured in serum (trough).

What toxicity threshold is taught for Phenytoin Level?

For Phenytoin Level, the commonly taught toxicity threshold is: > 20 µg/mL (nystagmus, ataxia); > 30 confusion.

Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population - always use the range printed on the actual result.

At the bedside

Nursing considerations

  • Toxicity progresses from nystagmus to ataxia to lethargy as levels climb.
  • Correct the measured level for low albumin, or measure free phenytoin.
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