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Therapeutic Drug Levels

Acetaminophen Level

Normal range 10-30 (therapeutic) µg/mL (66-199 µmol/L SI). Specimen: Serum (timed after ingestion).

Also known as: paracetamol level, APAP.

10-30 (therapeutic) µg/mLToxicity threshold: read below

Reference range

Conventionalµg/mL
1030
SIµmol/L
66199

Combined adult band. LabVals does not publish separate men's, women's, or pediatric ranges for Acetaminophen Level; those can be narrower than the band shown.

Acetaminophen Level reference range, specimen, and conversion details
SpecimenSerum (timed after ingestion)
Conventional range10-30 (therapeutic) µg/mL
SI range66-199 µmol/L
Conversion factor×6.62 (conventional → SI)
Toxicity threshold> 150 µg/mL at 4 h post-ingestion risks hepatotoxicity
PanelTherapeutic Drug Levels

Convert any Acetaminophen Level result between units on the unit converter.

What is the normal range for Acetaminophen Level?

The standard teaching reference range for Acetaminophen Level is 10-30 (therapeutic) µg/mL in conventional units, or 66-199 µmol/L in SI units. This value is measured in serum (timed after ingestion).

What toxicity threshold is taught for Acetaminophen Level?

For Acetaminophen Level, the commonly taught toxicity threshold is: > 150 µg/mL at 4 h post-ingestion risks hepatotoxicity.

Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population - always use the range printed on the actual result.

At the bedside

Nursing considerations

  • Plot the 4-hour level on the Rumack-Matthew nomogram to guide treatment.
  • N-acetylcysteine is the antidote and is most effective early.
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